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267 Results for 'Therapeutics & Vaccines'
PAGE 4 OF 11
Technology
Influenza M2 Protein Mutant Viruses As Influenza Live Attenuated Vaccines
A method to prepare recombinant influenza viruses comprising a mutant M2 protein which has a deletion of two or more residues in the cytoplasmic tail and is attenuated in vivo, is provided, as well th...
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Yoshihiro Kawaoka, Tokiko Watanabe | P07509US
Technology
Once-A-Week Administration Of 25-Hydroxy Vitamin D3 To Sustain Elevated Steady-State Pharmacokinetic Blood Concentration
An oral dosage form comprising a single dose of 25-hydroxy-vitamin D3 sufficient to elevate the serum level in a human to a concentration in the range of 30 ng/ml to 200 ng/ml for at least 7 days and ...
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Hector DeLuca, Lori Plum, Margaret Clagett-Dame | P08138US02
Technology
2-methylene-(20s,25r)-19,26-dinor-vitamin D Analogs
This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This comp...
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Hector DeLuca, Lori Plum, Margaret Clagett-Dame, Grazia Chiellini, Pawel Grzywacz | P08090US
Technology
Reversible Natural Product Glycosyltransferase-catalyzed Reactions, Compounds And Related Methods
The present invention relates to methods of use of glycosyltransferases and related compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomol...
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Jon Thorson, Byron Griffith, Changsheng Zhang | P06427US
Technology
Methods For Preventing And Attenuating Hyperphosphatemia
It is disclosed here a method for reducing phosphate absorption in a human or non-human animal subject wherein the subject consumes a diet containing phytic acid or phytate and either has or is at ris...
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Mark Cook, Keith Crawford, Erica Hellestad, Martin Petkovich, Christian Helvig | P06481US
Technology
Compositions And Methods For Treating Hyperphosphatemia In Humans
A method for reducing phosphate absorption in a human or non-human animal subject at risk of developing or having developed hyperphosphatemia is disclosed. The method includes the step of administerin...
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Mark Cook, Keith Crawford, Erica Hellestad, Christian Helvig, Martin Petkovich | P07020US
Technology
2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin D3 And Uses Thereof
This invention relates to vitamin D compounds, and more particularly to 2-methylene-1 α,25-dihydroxy-18,19,21-trinorvitamin D3 (DJ-55) and to pharmaceutical formulations that include this compound. T...
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Hector DeLuca, Rafal Barycki, Lori Plum, Margaret Clagett-Dame | P06327US
Technology
2-methylene-1alpha-hydroxy-18,19,21-trinorvitamin D3 Analogs And Uses Thereof
This invention relates to vitamin D compounds, and more particularly to 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 (SX-99) and to pharmaceutical formulations that include this compound. The inv...
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Hector DeLuca, Rafal Barycki, Lori Plum, Margaret Clagett-Dame | P06328US
Technology
2-methylene-19-nor-(23s)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone And 2-methylene-19-nor-(2
The invention provides 2-methylene-19-nor-(23R)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone (“GC-3”), 2-methylene-19-nor-(23S)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone (“HLV”), and re...
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Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Pawel Grzywacz, Grazia Chiellini | P05291US
Technology
19,26,27-trinor-1alpha,25-dihydroxyvitamin D3 Compounds
This invention relates to vitamin D compounds, and more particularly to 19,26,27-trinor-1α,25-dihydroxyvitamin D3 compounds such as 2α-methyl-19,26,27-trinor-(20S)-1α,25-dihydroxyvitamin D3 (“P...
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Hector DeLuca, Lori Plum, Pawel Grzywacz, Margaret Clagett-Dame | P05370US
Technology
Use Of Botulinum Toxin For The Treatment Of Hypervolemic Lip Deformity (lip Ectropion)
The present invention uses pharmaceutical preparations of Botulinum toxin to induce neurogenic atrophy to alter muscle volume and subsequently, facial contour. Reduction in lip volume is accomplished ...
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Gary Borodic | P05407US
Technology
17,20(z)-dehydro Vitamin D Analogs And Their Uses
This invention discloses 17,20(Z)-dehydro vitamin D analogs, and specifically 17(Z)-1α,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibi...
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Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Bulli Padmaja Tadi | P06097US
Technology
17,20(e)-dehydro Vitamin D Analogs And Their Uses
This invention discloses 17,20(E)-dehydro vitamin D analogs, and specifically 17(E)-1α,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibi...
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Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Bulli Padmaja Tadi | P06117US
Technology
Metabolic-based Methods For Modulating Gene Expression
This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
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Thomas Sutula, Avtar Roopra, Barry Schoenike | P05137US
Technology
2alpha-methyl-19-nor-(20s)-1alpha-hydroxy-bishomopregnacalciferol And Its Uses
This invention discloses 2α-methyl-19-nor-(20S)-vitamin D analogs, and specifically 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibit...
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Hector DeLuca, Lori Plum, Rafal Sicinski, Margaret Clagett-Dame | P05163US
Technology
Compounds And Methods For Treating Seizure Disorders
This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.
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Thomas Sutula, Avtar Roopra, Steven Kriegler, Carl Stafstrom | P04134US
Technology
Treatment Of Sinusitis Related Chronic Facial Pain And Headache With Botulinum Toxin Injections
The present invention provides methods for treating sinus-evoked headaches using botulinum toxin injected or applied in multiple subcutaneous locations over divisions of the trigeminal nerve in soft t...
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Gary Borodic, Martin Acquadro | P05053US
Technology
Composition For Therapeutic And Cosmetic Botulinum Toxin
This invention relates to a composition of botulinum based pharmaceuticals used for therapeutic and cosmetic treatment. This invention offers an improvement on the prior art by eliminating the potenti...
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Gary Borodic | P05055US
Technology
2-methylene-19,26,27-trinor-(20s)-1alpha-hydroxyvitamin D3 And Its Uses
This invention discloses 2-methylene-19,26,27-trinor-(20S)-vitamin D analogs, and specifically 2-methylene-19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and pharmaceutical uses therefor. This compound e...
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Hector DeLuca, Pawel Grzywacz, Lori Plum, Margaret Clagett-Dame | P05125US
Technology
2alpha-methyl And 2beta- Methyl Analogs Of 19,26,27-trinor-(20s)-1alpha-hydroxyvitamin D3 And Their
This invention discloses 2α-methyl and 2β-methyl analogs of 19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting the...
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Hector DeLuca, Pawel Grzywacz, Lori Plum, Margaret Clagett-Dame | P05127US
Technology
1-Alpha, 25-Dihydroxy-24,24-Difluoro-19-Nor-Vitamin D3 Analogs And Their Pharmaceutical Uses
Disclosed are 1α,25-dihydroxy-24,24-difluoro-2-methylene-19-nor-vitamin D analogs and their pharmaceutical uses. These new vitamin D analogs are 19-nor-vitamin D analogs having two fluorine atom subs...
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Hector DeLuca, Lori Plum, Agnieszka Flores, Hazel Holden, James Thoden | P150305US02
Technology
Influenza Virus Replication For Vaccine Development
The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isola...
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Yoshihiro Kawaoka, Gabriele Neumann, Jihui Ping | P150360US02
Technology
Synthesis And Biological Activity Of 2-Methylene Analogs Of Calcitriol And Related Compounds
Disclosed are 2-methylene analogs of vitamin D3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylen...
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Hector DeLuca, Lori Plum, Rafal Sicinski, Izabela Sibilska-Kaminski | P160027US02
Technology
Simplified Structural Mimetics Of Aips As Quorum Sensing Inhibitors
Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or m...
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Helen Blackwell, Joseph Vasquez, Yiftah Tal Gan | P170030US02
Technology
Unimolecular Nanoparticles For Efficient Delivery Of Therapeutic Cationic Peptides
Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be u...
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Shaoqin Gong, Wei Xu, Yuyuan Wang, Fabao Liu | P170128US02