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267 Results for 'Therapeutics & Vaccines'
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Technology
Methods And Pharmaceutical Compositions For Treating Adverse Or Deleterious Sequellae Of Traumatic Brain Injury
This invention provides methods for reducing the extent and progression of traumatic brain injury and its deleterious sequellae specifically cognitive decline, post-traumatic epilepsy, post-traumatic ...
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Thomas Sutula, Elizabeth Hutchinson, M. Elizabeth Meyerand, Paul Rutecki | P100307US02
Technology
Method To Inhibit Neuropathic Pain By Intrathecal Injection Of Protein Phosphatases
A method and corresponding pharmaceutical composition to inhibit neuropathic pain by injecting intrathecally into a mammalian subject a neuropathic pain-inhibiting amount of a phosphatase falling with...
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Vjekoslav Miletic, Gordana Miletic | P110265US02
Technology
Combination Chemotherapy For The Treatment Of Cancer
The present disclosure provides compositions, methods and kits for the treatment of cancer. Particularly, the present disclosure provides synergistic compositions comprising at least one cytotoxic rib...
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Ronald Raines, Trish Hoang | P170199US02
Technology
Novel Aryl Hydrocarbon Receptor Ligands Derived From Kynurenine
The present invention relates to novel compounds which are aryl hydrocarbon receptor (AHR) ligands and uses thereof. Methods of activating the AHR receptor in a subject are also provided. The compound...
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Yongna Xing, Seunghyeon Seok, Zhi-Xiong Ma, John Feltenberger | P170316US02
Technology
Recombinant Influenza Viruses With Stabilized Ha For Replication In Eggs
Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified neuraminidases by influenza virus ...
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Yoshihiro Kawaoka, Shinya Yamada, Shiho Chiba | P180114US03
Technology
Compositions And Methods For The Inhibition Of Fibrosis
Described herein is a mono-end PEGyated functional upstream domain (FUD), pharmaceutical compositions, and its use to inhibit fibrosis such as organ fibrosis, idiopathic pulmonary fibrosis and fibrosi...
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Bianca Tomasini-Johansson, Glen Kwon, Pawel Zbyszynski, Nathan Sandbo, Ksenija Bernau | P180076US02
Technology
Versikine For Inducing And Potentiating An Immune Response
Disclosed are methods, kits, polypeptides, and pharmaceutical compositions for inducing an immune response in a subject, which may include a T-cell mediated immune response. The methods comprise admin...
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Fotios Asimakopoulos, Chelsea Hope | P160199US04
Technology
Method For The Design Of Fibrillar Collagen-Mimetic Peptide Self-Assemblies
Novel synthetic human scale collagen triple helices assemblies are disclosed. Methods of making self-assembling collagen mimetic peptides that self-assemble into human scale collagen are also disclose...
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Ronald Raines, Ismet Tanrikulu | P160154US02
Technology
Oligolactic Acid Conjugates And Micelles With Enhanced Anticancer Efficacy
The present technology relates generally to oligolactic acid conjugates of paclitaxel, rapamycin, selumetinib, and other anticancer agents, micelle compositions containing such conjugates and methods ...
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Glen Kwon, Yu Tong (Tony) Tam | P160169US02
Technology
A Human Pluripotent Stem Cell-Based Screening For Smooth Muscle Cell Differentiation And Disease
Methods of using a small molecule MYH11 agonist to inhibit intimal hyperplasia and to maintain a contractile phenotype in vitro and in vivo are described. Also described herein are methods for generat...
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James Thomson, Jue Zhang | P170313US02
Technology
Methods Of Expanding Hematopoietic Stem Cells, Compositions, And Methods Of Use Thereof
Described herein are methods of expanding a population of hematopoietic stem cells by contacting the population of hematopoietic stem cells with an effective amount of an inhibitor of G-protein couple...
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Emery Bresnick, Xin Gao, Kirby Johnson | P160034US02
Technology
Generation Of Therapeutic Cells Using Extracellular Components Of Target Organs
The invention relates to an ex vivo generated population of tissue-specific anti-inflammatory macrophages and methods of making and using such macrophages.
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Peiman Hematti, John Kink, Eric Schmuck, Amish Raval | P160278US01
Technology
Radiohalogenated Agents For In Situ Immune Modulated Cancer Vaccination
A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound tha...
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Jamey Weichert, Paul Sondel, Anatoly Pinchuk, Zachary Morris, Mario Otto, Bryan Bednarz | P160396US02
Technology
Targeted Radiotherapy Chelates For In Situ Immune Modulated Cancer Vaccination
The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound t...
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Jamey Weichert, Paul Sondel, Anatoly Pinchuk, Zachary Morris, Mario Otto, Bryan Bednarz, Peter Carlson | P160397US02
Technology
Nanoengineered Surfaces For Cancer Biomarker Capture
Described herein is cancer biomarker, e.g., a vesicle, capture surface that includes a substrate, a first plurality of nanoparticles attached to the substrate; a plurality of bifunctional tethers, whe...
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Seungpyo Hong, Michael Poellmann | P180105US02
Technology
An Ionic Liquid-Based Nanoemulsion Formulation For The Efficient Delivery Of Hydrophobic Therapeutic Agents
The present invention discloses an ionic liquid composition comprising an at least partially hydrophobic ionic liquid, wherein the at least partially hydrophobic ionic liquid comprises a dication comp...
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Sandro Mecozzi, Moira Esson | P180283US02
Technology
Procedure For Crystallization Of (22e)-(24r)-2-Methylene-22-Dehydro-1alpha,24,25-Trihydroxy-19-Nor-Vitamin D3
Disclosed are methods of purifying the compound (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 to obtain the compound in crystalline form. The methods typically include the ...
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Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Agnieszka Flores, James Thoden, Hazel Holden | P180077US02
Technology
Novel Adjuvant For Animal And Human Vaccines
Quil-A chitosan spherical nanostructure complexes as well as methods of making and using such complexes are disclosed herein. Also provided are Quil-A chitosan spherical nanostrucutres loaded with one...
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Adel Talaat, Shaswath Chandrasekar | P190189US02
Technology
Antibodies Targeting Glioblastoma Stem-Like Cells And Methods Of Use Thereof
The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
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Eric Shusta, Michael Zorniak, Paul Clark, Yongku Cho, Benjamin Umlauf, John Kuo | P180018US02
Technology
Mutations That Confer Genetic Stability To Additional Genes In Influenza Viruses
The disclosure provides for an isolated recombinant influenza virus having at least one of: a PB2 viral segment encoding PB2 with residue at position 540 that is not asparagine or a residue at positio...
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Yoshihiro Kawaoka, Yuri Furusawa | P190174US02
Technology
Humanized Cell Line
A mammalian or avian cell line that expresses high levels of human influenza virus receptors is provided. In one embodiment, the cell line supports human influenza virus, e.g., human A/H3 influenza vi...
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Yoshihiro Kawaoka, Kosuke Takada, Masaki Imai | P180301US03
Technology
Cyphomycin, Compositions And Uses Thereof
Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cypho...
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Cameron Currie, Timothy Bugni, Monica Pupo, David Andes, Humberto Ortega Dominguez | P180334US02
Technology
Biemamides And Related Scaffolds As Inhibitors Of Transforming Growth Factor-Beta Signaling
The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-β signaling and/or TGF-β induced epithelial mesenchymal transition...
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Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann | P180361US02
Technology
Genetically Modified Genes And Cells, And Methods Of Using Same For Silencing Virus Gene Expression
Genetically modified CCNT1 and XPO1 genes encoding proteins that inhibit virus infection in cells. The genetically modified CCNT1 gene encodes a protein with a C261Y substitution with respect to the h...
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Nathan Sherer, Ryan Behrens | P180284US02
Technology
Vectors For Eliciting Immune Responses To Non-Dominant Epitopes In The Hemagglutinin (Ha) Protein
Methods of preparing influenza viruses having altered immunodominant epitopes in HA, e.g., having one or more residues in one or more of antigenic sites A-E in HA altered, and viral vectors, e.g., inf...
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Yoshihiro Kawaoka, Gabriele Neumann, Huihui Kong | P190028US02