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324 Results for 'Research Tools'
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Technology
Transgenic Mice Containing an Antioxidant Response Element-Driven Reporter Gene
Antioxidant response elements (AREs) are small segments of DNA that turn on a wide variety of genes in response to oxidative stress. They are of particular interest in the study of cancer treatment an...
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Jeffrey Johnson, Delinda Johnson | P00333US
Technology
An Epitope Tag for Gentle Immunoaffinity Chromatography
Epitope tagging provides an improved method of protein immunopurification. The technique involves adding a small peptide epitope to a protein of interest through recombinant DNA techniques. The recomb...
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Richard Burgess, Nancy Thompson | P03006US
Technology
Electrospray Ionization Ion Source with Tunable Charge Reduction
Analysis by mass spectrometry requires that molecules first be converted to gas-phase ions. Converting small molecules into ions is straightforward; however, it was not possible to ionize large molecu...
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Lloyd Smith, Brian Frey, Michael Westphall | P05387US
Technology
Transgenic Mouse for Testing Chemotherapeutic Agents
The gene mdm2 is a negative regulator of p53, which plays a key role in apoptosis and is important in chemotherapy. Mice with knockout mutations in mdm2 would be useful in studying this gene; however,...
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Mary Ellen Perry, Susan Mendrysa | P00331US
Technology
Eight Hybridoma Cell Lines Producing Monoclonal Antibodies Against La Crosse Encephalitis Virus
La Crosse virus is an etiologic agent for childhood encephalitis in North America. Structurally, the nucleocapsid of this virus is enclosed by a host-derived lipid envelope holding two virion glycopro...
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Thomas Yuill | P01150US
Technology
Cell Line Stably Expressing the Human Heart Sodium Channel Beta1 Subunit
The human heart sodium channel beta1 subunit is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel.
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Jonathan Makielski, Bin Ye, Carmen Valdivia | P03206US
Technology
Expression and Purification of Recombinant Rabbit and Human Phosphoglucomutase
Phosphoglucomutase (PGM) is a glycolytic enzyme that converts glucose 1-phosphate to glucose 6-phosphate. This enzyme plays a major role in directing the flow of carbon toward either anabolic or catab...
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John Markley, Ronnie Frederick, Young Kee Chae | P02088US
Technology
Transgenic Rats Expressing Human Placental Alkaline Phosphatase
The ability to unambiguously mark a cell’s genotype is essential for studies in which genetically distinct cell populations must be distinguished from one another in vivo.
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Eric Sandgren, William Kisseberth, Jan Lohse, Phil Soriano | P01322US
Technology
Transgenic Mice Expressing Human Alkaline Phosphatase
The ability to unambiguously mark a cell’s genotype is essential for studies in which genetically distinct cell populations must be distinguished from one another in vivo.
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Eric Sandgren, William Kisseberth, Jan Lohse, Phil Soriano | P01323US
Technology
Transgenic Mice That Ubiquitously Express Enhanced Green Fluorescent Protein
The ability to unambiguously mark a cell’s genotype is essential for studies in which genetically distinct cell populations must be distinguished from one another in vivo.
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Eric Sandgren, William Kisseberth, Jan Lohse, Phil Soriano | P01324US
Technology
Bacterial Culture Collection from an Extreme Environment in Alaska
Microorganisms adapted to grow in exceptionally harsh environments, such as hot springs and arctic soils, are a potentially vast source of novel metabolic processes, antibiotics, enzymes and other pro...
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Jo Handelsman, Patrick Schloss | P03154US
Technology
Monoclonal Antibody to Eukaryotic RNA Polymerase II
The enzyme RNA polymerase II synthesizes precursors to mRNAs and small nuclear RNAs. Sequence analysis of the largest subunit of RNA polymerase II has revealed an unusual heptapeptide repeat at the mo...
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Richard Burgess, Nancy Thompson | P03157US
Technology
Unique, Full-Length Mouse cDNAs
The study of full-length cDNA clones is important for determining the structure and function of genes.
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Christopher Bradfield | P03413US
Technology
Novel Assay for Measuring Stress-Induced CREB Phosphorylation
CREB is a transcription factor that has been implicated as a critical regulator of neuronal function and survival. Knockout mice lacking CREB exhibit a disease similar to ataxia telangiectasia, a neur...
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Randal Tibbetts, Yuling Shi | P04048US
Technology
Rat Strain Showing Developmental Changes in Alternative Splicing of the Heart Protein Titin
Titin is a very large cardiac protein that determines the resting tension of the heart in rats. Isoforms of titin are generated by alternative splicing of a single titin gene. Titin in embryonic rat h...
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Marion Greaser, Chad Warren, Paul Krzesinski | P04176US
Technology
Libraries of Bacterial Genomic DNA Isolated from Alaskan Soils
Cultured microorganisms produce an extraordinary array of structurally diverse and valuable organic compounds; however, microbes that can be brought into culture by standard techniques represent only ...
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Jo Handelsman, Lynn Williamson | P04104US
Technology
Strain and Vector for Use with the Three Hybrid System
Three hybrid screens are used to detect RNA-protein interactions. A problem with three hybrid screens has been high background due to some cDNAs binding and activating transcription in the absence o...
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Marvin Wickens, Beilin Zhang | P97099US
Technology
Label-Free, Radio-Frequency Detection of DNA Hybridization at Microelectrodes
Most of today’s technologies for detecting DNA hybridization – the binding of a DNA strand to its complementary strand – require the use of fluorescent tags or other types of labels.
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Daniel van der Weide, Robert Hamers, Wei Cai, John Peck | P03002US
Technology
Method and Device for Measuring Electrical Conductance of Membranes with a Radio Frequency Probe
Biological membranes, such as cell membranes, are intrinsically impermeable to ions and polar molecules. Thus, transport of ions through biological membranes requires special channel or pump proteins ...
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Daniel van der Weide | P01413US
Technology
Heterogeneous Protein Foldamers Containing Alpha, Beta and Gamma Amino Acids
Foldamers are synthetic protein oligomers with discrete and predictable folding properties akin to those of natural proteins. They provide molecular tools to investigate large-molecule interactions su...
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Samuel Gellman, Ahlke Hayen, Margaret Schmitt, Felix Ngassa | P02125US
Technology
HERG-Specific Antisera
The gene HERG1 encodes a potassium-selective ion channel important in maintaining normal cardiac rhythm and cell growth.
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Gail Robertson, Barry London, Elon Roti Roti, Samantha Delfosse, Eugenia Jones | P04019US
Technology
Controllable Murine Models of First Pass Metabolism
The liver detoxifies many of the drugs and toxins in blood, which poses a problem in drug development and testing because drugs are rapidly cleared from the system. In the mammalian fetus, the liver i...
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Christopher Bradfield, Jacqueline Walisser, Tami Thomae | P04330US
Technology
A Polyclonal Antibody Directed Against the C-Terminus of HERG
HERG (human ether-a-go-go-related gene) encodes a potassium ion channel important for maintaining normal cardiac rhythm and cell growth.
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Craig January, Qiuming Gong, Zhengfeng Zhou | P05253US
Technology
10,000 Sequenced Mouse Genomic Clones Derived From a CpG Library
CpG islands are areas of DNA containing a high CpG content, which often correspond to promoter regions.
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Peggy Farnham | P04394US
Technology
HERG CDNA with Native PolyA Tail
The human ERG gene encodes a potassium channel that is expressed in the heart. Mutations in the HERG channel are a common cause of long QT syndrome, a disorder associated with delayed cardiac repolari...
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Gail Robertson, Eugenia Jones, Blake Anson | P05401US