HERG (human ether-a-go-go-related gene) encodes a potassium ion channel important for maintaining normal cardiac rhythm and cell growth.
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CpG islands are areas of DNA containing a high CpG content, which often correspond to promoter regions.
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The human ERG gene encodes a potassium channel that is expressed in the heart. Mutations in the HERG channel are a common cause of long QT syndrome, a disorder associated with delayed cardiac repolari...
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Cardiac IKr channels are targets associated with inherited and acquired long QT syndrome (LQTS), a disorder that can lead to ventricular arrhythmias. Previously, IKr channels were thought to be compos...
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The human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is...
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Cultured microorganisms produce an extraordinary array of structurally diverse and valuable organic compounds; however, microbes that can be cultured using standard techniques represent only a small f...
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Most biochemical interactions are studied in solutions containing dilute concentrations of molecules. However, the complexity of the cellular environment makes it difficult to compare the results of s...
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No well-characterized prostate stromal cell lines currently exist.
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The six mammalian actin genes encode a highly conserved family of cytoskeletal protein isoforms important in cell structure, mechanical stability, and motility. Actin isoforms exhibit tissue-specific ...
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The human either-a-go-go related gene (HERG1 or KCNH2) potassium channel is critical to maintaining normal cardiac rhythm. Because unintended block of HERG channel activity by drugs can cause long QT ...
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Because they retain large DNA inserts over many generations, bacterial artificial chromosomes (BACs) are popular vectors for genetic and expression analyses of genomic DNA libraries; however, their us...
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Promoters are genetic regulatory elements that drive gene expression in cells under certain conditions. One way to identify promoters is to use a promoter-trap vector, which is a plasmid containing a ...
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Microorganisms adapted to grow in exceptionally harsh environments, such as hot springs and arctic soils, are a potentially vast source of novel metabolic processes, antibiotics, enzymes and other pro...
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Microorganisms adapted to grow in exceptionally harsh environments, such as hot springs and arctic soils, are a potentially vast source of novel metabolic processes, antibiotics, enzymes and other pro...
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Humans with mutations in the Adenomatous Polyposis Coli (APC) gene develop hundreds or even thousands of adenomas in the colon, which often lead to colorectal cancer. Mouse models of human intestinal ...
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Actinomycetes, which are Gram-positive filamentous bacteria, produce the majority of known antibiotics. Fungus-growing Attine ants engage in a mutualistic association with actinomycetes to defend thei...
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Because conventional DNA sequencing using electrophoresis is laborious and time consuming, alternative approaches, such as those using microarrays, have been developed. Photolithographic techniques ar...
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Functional genomics involves identifying the function of all genes within a sequenced genome. Knockout mutants may be used to identify the in situ function of any gene, without making assumptions abou...
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Much of the research on RNA transcription is focused on the action of RNA polymerases. Thus, improved methods for purifying and characterizing RNA polymerase greatly enhance studies of transcription. ...
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Re-polarization of the cardiac action potential, which plays a critical role in maintaining normal cardiac rhythm, occurs mainly due to the action of potassium ion (K+) currents in the heart. The most...
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Controlled micrometer-scale oil droplets have applications in nano-materials, meso-materials, responsive materials, optical materials, filters, sensors and opto-electronic technologies.  Emulsion dro...
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Circulating tumor cells (CTC) are an important area of cancer research.  They could provide clinically relevant information about a patient’s prognosis.  However, these cells are extremely rare (r...
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Few treatments for neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, have been discovered.  In many cases, the molecular basis for neurodegeneration remains unknown...
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The low mobility of bacterial transposons, such as Tn5, makes it difficult for researchers to detail the molecular transposition process and to exploit transposition for uses such as the development o...
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Over the last eight years, academic researchers have been developing a new set of spectroscopic techniques that are multidimensional versions of visible and infrared spectroscopies, such as two-dimens...
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